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TXNRD1 Antikörper

This anti-TXNRD1 antibody (ABIN2855577) is a Rabbit Polyclonal antibody detecting TXNRD1 in WB, ICC, IF, IHC (p). Suitable for Human.
Produktnummer ABIN2855577

Kurzübersicht für TXNRD1 Antikörper (ABIN2855577)

Target

Alle TXNRD1 Antikörper anzeigen
TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Reaktivität

  • 46
  • 30
  • 27
Human

Wirt

  • 45
  • 6
  • 1
Kaninchen

Klonalität

  • 39
  • 13
Polyklonal

Konjugat

  • 26
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TXNRD1 Antikörper ist unkonjugiert

Applikation

  • 41
  • 16
  • 15
  • 13
  • 13
  • 11
  • 10
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Kreuzreaktivität

    Human, Maus

    Produktmerkmale

    Rabbit polyclonal antibody to TrxR1 (thioredoxin reductase 1)
    TrxR1 antibody [N1N3]

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human TrxR1. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: HepG2

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

    Andere Bezeichnung

    thioredoxin reductase 1

    Hintergrund

    This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.

    Cellular Localization: Cytoplasm , Isoform 4: Cytoplasm , Nucleus , Isoform 5: Cytoplasm

    Molekulargewicht

    71 kDa

    Gen-ID

    7296

    UniProt

    Q16881

    Pathways

    Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis
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