PSMA7 Antikörper (Center)
Kurzübersicht für PSMA7 Antikörper (Center) (ABIN2855151)
Target
Alle PSMA7 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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                                            Bindungsspezifität
- Center
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                                            Kreuzreaktivität
- Huhn, Schwein, Ratte (Rattus), Rind (Kuh), Xenopus tropicalis
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                                            Kreuzreaktivität (Details)
- Chicken (96 %), Pig (98 %), Rat (98 %), Bovine (99 %), Xenopus tropicalis (97 %)
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                                            Produktmerkmale
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                        Rabbit Polyclonal antibody to PSMA7 (proteasome (prosome, macropain) subunit, alpha type, 7)
 PSMA7 antibody [N1C3]
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                                            Aufreinigung
- Purified by antigen-affinity chromatography.
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                                            Immunogen
- Recombinant protein encompassing a sequence within the center region of human Proteasome 20S alpha 7. The exact sequence is proprietary.
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                                            Isotyp
- IgG
 
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                                            Applikationshinweise
- Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
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                                            Kommentare
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                        Positive Control: 293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , mouse brain 
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Liquid
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                                            Konzentration
- 0.32 mg/mL
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                                            Buffer
- 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
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                                            Konservierungsmittel
- Thimerosal (Merthiolate)
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                                            Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            Lagerung
- -20 °C
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                                            Informationen zur Lagerung
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
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    - PSMA7 (Proteasome Subunit alpha 7 (PSMA7))
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                                            Andere Bezeichnung
- PSMA7
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                                            Hintergrund
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                        The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9. 
 Cellular Localization: Cytoplasm , Nucleus
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                                            Molekulargewicht
- 28 kDa
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                                            Gen-ID
- 5688
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                                            Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
 Target
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