GLA Antikörper

Produktnummer ABIN2854962

Dieses Anti-GLA-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GLA in WB, IP und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für GLA Antikörper (ABIN2854962)

Target: GLA (Galactosidase, alpha (GLA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: KO Validated

Produktdetails anti-GLA Antikörper

Spezifität: Knockdown/Knockout validation was supported by customer review data.

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to Galactosidase alpha (galactosidase, alpha)
Galactosidase alpha antibody [N1C2]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Galactosidase alpha. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: HeLa , 293T , Rat lung

Validation: KO/KD

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.157 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-GLA Antikörper (ABIN2854962)

Ivanova, Dao, Kasaci, Adewale, Fikry, Goker-Alpan: "Rapid Clathrin-Mediated Uptake of Recombinant α-Gal-A to Lysosome Activates Autophagy." in: Biomolecules, Vol. 10, Issue 6, (2020) (PubMed).

Hingorani, Metcalf, Deming, Garman, Powers, Gierasch: "Ligand-promoted protein folding by biased kinetic partitioning." in: Nature chemical biology, Vol. 13, Issue 4, pp. 369-371, (2017) (PubMed).

Details zu GLA

Target: GLA (Galactosidase, alpha (GLA))

Andere Bezeichnung: galactosidase alpha

Hintergrund: This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Cellular Localization: Lysosome

Molekulargewicht: 49 kDa

Gen-ID: 2717

UniProt: P06280

Pathways: SARS-CoV-2 Protein Interaktom