LIG1 Antikörper (C-Term)
Kurzübersicht für LIG1 Antikörper (C-Term) (ABIN2854412)
Target
Alle LIG1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- C-Term
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Kreuzreaktivität
- Human
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Produktmerkmale
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Rabbit polyclonal antibody to DNA ligase I (ligase I, DNA, ATP-dependent)
DNA ligase I antibody [C2C3], C-term -
Aufreinigung
- Purified by antigen-affinity chromatography.
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Immunogen
- Recombinant protein encompassing a sequence within the C-terminus region of human DNA ligase I. The exact sequence is proprietary.
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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Kommentare
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Positive Control: A431 , H1299
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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Konservierungsmittel
- Thimerosal (Merthiolate)
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Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase." in: Nucleic acids research, Vol. 47, Issue 5, pp. 2402-2424, (2019) (PubMed).
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: "DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase." in: Nucleic acids research, Vol. 47, Issue 5, pp. 2402-2424, (2019) (PubMed).
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- LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))
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Andere Bezeichnung
- DNA ligase 1
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Hintergrund
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LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.
Cellular Localization: Nucleus -
Molekulargewicht
- 102 kDa
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Gen-ID
- 3978
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UniProt
- P18858
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Pathways
- Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA
Target
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