ALDH2 Antikörper

Produktnummer ABIN1881053

Produktdetails anti-ALDH2 Antikörper

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALDH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Immunogen: This ALDH2 antibody is generated from rabbits immunized with human ALDH2 recombinant protein.

Klon: RB23145

Anwendungsinformationen

Applikationshinweise: WB: 1:1000,IHC (p): 1:50-100,FACS: 1:10-50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.33 mg/mL

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Referenzen für anti-ALDH2 Antikörper (ABIN1881053)

Guo, Wang, Liu, Chen, Qi, Guo: "Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males." in: World journal of gastroenterology : WJG, Vol. 14, Issue 9, pp. 1444-9, (2008) (PubMed).

Chen, Smith, Harbord, Lewis: "Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach." in: PLoS medicine, Vol. 5, Issue 3, pp. e52, (2008) (PubMed).

Teeguarden, Bogdanffy, Covington, Tan, Jarabek: "A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry." in: Inhalation toxicology, Vol. 20, Issue 4, pp. 375-90, (2008) (PubMed).

Details zu ALDH2

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Andere Bezeichnung: ALDH2 (ALDH2 Produkte)

Hintergrund: ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme.

Synonyms: ALDH2, ALDM, Aldehyde dehydrogenase, mitochondrial, ALDH class 2, ALDH-E2, ALDHI

NCBI Accession: NP_000681, NP_001191818

UniProt: P05091