KLF4 Antikörper (N-Term)

Produktnummer ABIN389188

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KLF4 in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für KLF4 Antikörper (N-Term) (ABIN389188)

Target: KLF4 (Kruppel-Like Factor 4 (Gut) (KLF4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB14261

Produktdetails anti-KLF4 Antikörper

Bindungsspezifität: AA 20-53, N-Term

Spezifität: This KLF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20~50 amino acids from the N-terminal region of human KLF4.

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This KLF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-53 AA from the N-terminal region of human KLF4.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB = 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-KLF4 Antikörper (ABIN389188)

Xu, Sun, Zhang, Jiang, Zhang, Zhou, Ding, Hu, Yan: "MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4." in: Molecular and cellular endocrinology, Vol. 452, pp. 138-147, (2018) (PubMed).

Yan, Yu, Liu, Kang, Ma, Zhou: "MiR-32 promotes gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4." in: Biochemical and biophysical research communications, Vol. 467, Issue 4, pp. 913-20, (2015) (PubMed).

Jumabay, Abdmaulen, Ly, Cubberly, Shahmirian, Heydarkhan-Hagvall, Dumesic, Yao, Boström: "Pluripotent stem cells derived from mouse and human white mature adipocytes." in: Stem cells translational medicine, Vol. 3, Issue 2, pp. 161-71, (2014) (PubMed).

Marini, Porcu, Asunis, Loi, Ristaldi, Porcu, Ikuta, Cao, Moi: "Regulation of the human HBA genes by KLF4 in erythroid cell lines." in: British journal of haematology, Vol. 149, Issue 5, pp. 748-58, (2010) (PubMed).

Details zu KLF4

Target: KLF4 (Kruppel-Like Factor 4 (Gut) (KLF4))

Andere Bezeichnung: KLF4

Hintergrund: Kruppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon. It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene. KLF4 is also involved in reprogramming differentiated cells into pluripotent stem cells. KLF4 can act as a transcriptional activator or repressor, but the underlying mechanisms are poorly understood.
Synonyms: Kruppel-like factor 4, EZF, GKLF

Molekulargewicht: 50945 DA

Gen-ID: 9314

NCBI Accession: NP_004226

Pathways: Peptide Hormone Metabolism, Stem Cell Maintenance