USP7 Antikörper (Center)

Produktnummer ABIN2799159

Dieses Anti-USP7-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von USP7 in WB. Geeignet für Human.

Kurzübersicht für USP7 Antikörper (Center) (ABIN2799159)

Target: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-USP7 Antikörper

Bindungsspezifität: AA 320-348, Center

Verwendungszweck: Rabbit Anti-Human USP7 (Center) Antibody

Immunogen: This USP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-348 amino acids from the Central region of human USP7.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot
Recommended Dilutions
WB: 1:1000USP7 Antibody (Center) .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.450 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu USP7

Target: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Andere Bezeichnung: USP7

Hintergrund:

Target Description: Hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. Deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.

Gene Symbol: USP7

Molekulargewicht: 128302 Da

Gen-ID: 7874

UniProt: Q93009