Nanog Antikörper (AA 267-292)
Kurzübersicht für Nanog Antikörper (AA 267-292) (ABIN2798794)
Target
Alle Nanog (NANOG) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 267-292
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Verwendungszweck
- Rabbit Anti-Human NANOG (S285) Antibody
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Immunogen
- This NANOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-292 amino acids from human NANOG.
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Isotyp
- Ig Fraction
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Applikationshinweise
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Western Blot, Immunofluorescence
Recommended Dilutions
WB: 1:1000, IF: 1:10-50Western blot analysis of NANOG (arrow) using rabbit NANOG Antibody (S285) . Nanog immunoreactivity is localized mainly to the nuclei and also to the cytoplasm. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 0.310 mg/mL
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- 2-8°C (short-term), -20°C (long-term)
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- Nanog (NANOG) (Nanog Homeobox (NANOG))
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Andere Bezeichnung
- NANOG
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Hintergrund
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Target Description: NANOG is a Ttranscription regulator involved in inner cell mass and embryonic stem (ES) cels proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.
Gene Symbol: NANOG
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Molekulargewicht
- 34620 Da
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Gen-ID
- 79923
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UniProt
- Q9H9S0
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Pathways
- Stem Cell Maintenance
Target
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