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WDR48 Antikörper (WD Repeat Domain 48) C-Term Primary Antibody

WDR48 Reaktivität: Human FACS, IHC, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2797022
$391.60
Zzgl. Versandkosten $45.00
400 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 6 bis 8 Werktagen
  • Target Alle WDR48 Antikörper anzeigen
    WDR48
    Bindungsspezifität
    • 10
    • 10
    • 8
    AA 603-630, C-Term
    Reaktivität
    • 22
    • 4
    • 3
    Human
    Wirt
    • 23
    Kaninchen
    Klonalität
    • 23
    Polyklonal
    Konjugat
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser WDR48 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 18
    • 16
    • 15
    • 5
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
    Verwendungszweck
    Rabbit Anti-Human WDR48 (C-term) Antibody
    Immunogen
    This WDR48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-630 amino acids from the C-terminal region of human WDR48.
    Isotyp
    Ig Fraction
  • Applikationshinweise
    Western Blot, Immunohistochemistry, Flow Cytometry
    Recommended Dilutions
    WB: 1:1000, IHC: 1:50-100, FC: 1:10-50WDR48 Antibody (C-term) .FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    2-8°C (short-term), -20°C (long-term)
  • Target
    WDR48
    Andere Bezeichnung
    WDR48 (WDR48 Produkte)
    Synonyme
    P80, UAF1, 8430408H12Rik, mKIAA1449, WD repeat domain 48, WDR48, Wdr48
    Hintergrund

    Target Description: Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

    Gene Symbol: WDR48

    Molekulargewicht
    76210 Da
    Gen-ID
    57599
    UniProt
    Q8TAF3
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