WDR48 Antikörper (C-Term)

Produktnummer ABIN2797022

Der Kaninchen Polyklonal Anti-WDR48-Antikörper wurde für WB, IHC und FACS validiert. Er ist geeignet, WDR48 in Proben von Human zu detektieren.

Kurzübersicht für WDR48 Antikörper (C-Term) (ABIN2797022)

Target: WDR48 (WD Repeat Domain 48 (WDR48))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WDR48 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-WDR48 Antikörper

Bindungsspezifität: AA 603-630, C-Term

Verwendungszweck: Rabbit Anti-Human WDR48 (C-term) Antibody

Immunogen: This WDR48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-630 amino acids from the C-terminal region of human WDR48.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot, Immunohistochemistry, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100, FC: 1:10-50WDR48 Antibody (C-term) .FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu WDR48

Target: WDR48 (WD Repeat Domain 48 (WDR48))

Andere Bezeichnung: WDR48

Hintergrund:

Target Description: Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

Gene Symbol: WDR48

Molekulargewicht: 76210 Da

Gen-ID: 57599

UniProt: Q8TAF3