Neuregulin 3 Antikörper (C-Term)

Produktnummer ABIN2794837

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Neuregulin 3 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Neuregulin 3 Antikörper (C-Term) (ABIN2794837)

Target: Neuregulin 3 (NRG3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Neuregulin 3 Antikörper

Bindungsspezifität: AA 688-717, C-Term

Verwendungszweck: Rabbit Anti-Human NRG3 (C-term) Antibody

Immunogen: This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 688-717 amino acids from the C-terminal region of human NRG3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50NRG3 Antibody (E703) for immunohistochemistry. Clinical relevance has not been evaluated.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu Neuregulin 3

Target: Neuregulin 3 (NRG3)

Andere Bezeichnung: NRG3

Hintergrund:

Target Description: NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Gene Symbol: NRG3

Molekulargewicht: 77901 Da

Gen-ID: 10718

UniProt: P56975

Pathways: RTK Signalweg