MAP3K4 Antikörper (AA 235-264)
Kurzübersicht für MAP3K4 Antikörper (AA 235-264) (ABIN2793281)
Target
Alle MAP3K4 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 235-264
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Verwendungszweck
- Rabbit Anti-Human MEKK4 (MAP2K4) (S257) Antibody
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Immunogen
- This MEKK4(MAP2K4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from human MEKK4(MAP2K4).
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Isotyp
- Ig Fraction
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Applikationshinweise
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Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50Western blot analysis of MAP2K4 (arrow) using rabbit polyclonal MAP2K4 Antibody (S257) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 0.350 mg/mL
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- 2-8°C (short-term), -20°C (long-term)
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- MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
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Andere Bezeichnung
- MEKK4
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Hintergrund
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Target Description: MAP2K4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. MAP2K4 is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
Gene Symbol: MAP2K4
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Molekulargewicht
- 44288 Da
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Gen-ID
- 6416
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UniProt
- P45985
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Pathways
- MAPK Signalweg
Target
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