EN1 Antikörper (C-Term)

Produktnummer ABIN2792656

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-EN1 Antikörper wird verwendet zum Nachweis von EN1 in Proben von Meerschweinchen und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für EN1 Antikörper (C-Term) (ABIN2792656)

Target: EN1 (Engrailed Homeobox 1 (EN1))

Reaktivität: Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-EN1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: EN1 Antibody - C-terminal region

Sequenz: LMGSANGGPV VKTDSQQPLV WPAWVYCTRY SDRPSSGPRT RKLKKKKNEK

Kreuzreaktivität: Huhn, Human, Maus

Homologie: Guinea Pig: 93%, Rabbit: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against EN1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-EN1 Antikörper (ABIN2792656)

Beltran, Graves, Blancafort: "Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function." in: Oncogene, Vol. 33, Issue 39, pp. 4767-77, (2014) (PubMed).

Details zu EN1

Target: EN1 (Engrailed Homeobox 1 (EN1))

Andere Bezeichnung: EN1

Hintergrund:

Background Information: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Engrailed homeobox 1

Alternative Symbols: ENDOVESLB

Protein Name: Homeobox protein engrailed-1

Molekulargewicht: 40kDa

Gen-ID: 2019

NCBI Accession: NP_001417

UniProt: Q05925

Pathways: Dopaminergic Neurogenesis