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EN1 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-EN1-Antikörper wurde für WB validiert. Er ist geeignet, EN1 in Proben von Meerschweinchen und Kaninchen zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN2792656

Kurzübersicht für EN1 Antikörper (C-Term) (ABIN2792656)

Target

Alle EN1 Antikörper anzeigen
EN1 (Engrailed Homeobox 1 (EN1))

Reaktivität

  • 33
  • 21
  • 20
  • 6
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Meerschweinchen, Kaninchen

Wirt

  • 37
  • 1
Kaninchen

Klonalität

  • 34
  • 4
Polyklonal

Konjugat

  • 13
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser EN1 Antikörper ist unkonjugiert

Applikation

  • 27
  • 16
  • 13
  • 13
  • 8
  • 7
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 16
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term

    Sequenz

    LMGSANGGPV VKTDSQQPLV WPAWVYCTRY SDRPSSGPRT RKLKKKKNEK

    Kreuzreaktivität

    Huhn, Human, Maus

    Homologie

    Guinea Pig: 93%, Rabbit: 86%

    Produktmerkmale

    This is a rabbit polyclonal antibody against EN1. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the C terminal region of human EN1
  • Applikationshinweise

    WB Suggested Anti-EN1 Antibody Titration: 0.2-1 µg/mL
    ELISA Titer: 1:312500
    Positive Control: HepG2 cell lysate.
    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 392 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Beltran, Graves, Blancafort: "Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function." in: Oncogene, Vol. 33, Issue 39, pp. 4767-77, (2014) (PubMed).

  • Target

    EN1 (Engrailed Homeobox 1 (EN1))

    Andere Bezeichnung

    Engrailed-1 / EN1

    Hintergrund

    Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: -
    Protein Interaction Partner: TLE1, PAX6, JUN,
    Protein Size: 392

    Molekulargewicht

    40 kDa

    Gen-ID

    2019

    NCBI Accession

    NM_001426, NP_001417

    UniProt

    Q05925

    Pathways

    Dopaminergic Neurogenesis
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