CTNNB1 Antikörper (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (C-Term)

Details for Product anti-CTNNB1 Antibody No. ABIN2792527, Anbieter: Anmelden zum Anzeigen
Antigen
  • Jup
  • LOC100217813
  • CTNNB1
  • CTNNB
  • Bfc
  • Catnb
  • Mesc
  • ctnnb
  • id:ibd2058
  • wu:fb73e10
  • wu:fi81c06
  • wu:fk25h01
  • ctnnb1
  • CHBCAT
  • MRD19
  • armadillo
  • beta-catenin
  • catenin beta 1
  • catenin (cadherin associated protein), beta 1
  • catenin (cadherin-associated protein), beta 1
  • catenin beta 1 S homeolog
  • catenin beta 1 L homeolog
  • CTNNB1
  • Ctnnb1
  • ctnnb1
  • ctnnb1.S
  • ctnnb1.L
Epitop
C-Term
79
21
20
20
19
17
16
15
12
10
9
8
7
7
6
6
5
5
5
5
5
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Zebrafisch (Danio rerio)
481
213
190
62
53
41
25
25
21
21
14
14
14
10
9
8
3
1
1
1
1
1
1
Wirt
Kaninchen
309
184
7
2
Klonalität
Polyklonal
Konjugat
Dieser CTNNB1 Antikörper ist unkonjugiert
14
11
8
7
7
6
4
4
2
2
1
1
1
1
1
1
Applikation
Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
445
155
128
123
115
98
64
30
16
13
8
8
4
3
2
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the C-terminal region of human CTNNB1
Sequenz RTEPMAWNET ADLGLDIGAQ GEPLGYRQDD PSYRSFHSGG YGQDALGMDP
Kreuzreaktivität Rind (Kuh), Hund, Huhn, Human, Maus, Schwein, Ratte (Rattus)
Homologie Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Zebrafish: 100%
Produktmerkmale This is a rabbit polyclonal antibody against CTNNB1. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung CTNNB1 / Beta Catenin (CTNNB1 Antibody Abstract)
Hintergrund Beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.Beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-54 DA216720.1 1-54 55-2626 X87838.1 1-2572 2627-3720 AC104307.2 83770-84863
Alias Symbols: CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
Protein Interaction Partner: PPARD, PLA2G4A, FBXO45, BTRC, SUMO1, UBC, HUWE1, CDH5, CDH2, TCF4, TBL1X, SOX1, SKP1, RNF220, CACYBP, FBXW11, SUMO2, SIAH1, Apc2, COPS5, RNF14, CDH1, SP1, KCTD1, MDM2, UBE2B, GSK3B, NEK2, RBX1, PTGS2, STRN3, LATS2, APC, ELAVL1, AMOT, ABL1, AXIN1, CBL, LEF
Protein Size: 781
Molekulargewicht 85 kDa
Gen-ID 1499
NCBI Accession NM_001904, NP_001895
UniProt P35222
Pathways WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
Applikationshinweise WB Suggested Anti-CTNNB1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: Human heart.
Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 781 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) antibody (ABIN2792527) WB Suggested Anti-CTNNB1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
 image for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) antibody (ABIN2792527) anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) antibody (Image 2)
 image for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) antibody (ABIN2792527) anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) antibody (Image 3)
Chromatin Immunoprecipitation (ChIP) image for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) antibody (ABIN2792527) CTNNB1 Antibody - middle region (P100601_P050) validated by CHIP using HCT116 cell ly...
Chromatin Immunoprecipitation (ChIP) image for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) antibody (ABIN2792527) CTNNB1 Antibody - middle region (P100601_P050) validated by CHIP using HCT116 cell ly...
Chromatin Immunoprecipitation (ChIP) image for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) antibody (ABIN2792527) CTNNB1 antibody - middle region (P100601_P050) validated by CHIP using HCT116 cell ly...
Chromatin Immunoprecipitation (ChIP) image for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) antibody (ABIN2792527) CTNNB1 antibody - middle region (P100601_P050) validated by CHIP using HCT116 cell ly...
Produkt verwendet in: Li, Yang, Tang, Zhang, Feng, Cui: "Repair of massively defected hemi-joints using demineralized osteoarticular allografts with protected cartilage." in: Journal of materials science. Materials in medicine, Vol. 26, Issue 8, pp. 227, 2015 (PubMed).

Allgemeine Veröffentlichungen Jiang, Tan, Li, Kivimäe, Yang, Zhuang, Lee, Chan, Stanton, Liu, Cheyette, Yu: "DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications." in: Cancer cell, Vol. 13, Issue 6, pp. 529-41, 2008 (PubMed).

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