STX1A Antikörper (N-Term)

Produktnummer ABIN2792295

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch STX1A in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Hund und Meerschweinchen.

Kurzübersicht für STX1A Antikörper (N-Term) (ABIN2792295)

Target: STX1A (Syntaxin 1A (Brain) (STX1A))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STX1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-STX1A Antikörper

Bindungsspezifität: N-Term

Sequenz: KDRTQELRTA KDSDDDDDVA VTVDRDRFMD EFFEQVEEIR GFIDKIAENV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against STX1A. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STX1A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 288 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu STX1A

Target: STX1A (Syntaxin 1A (Brain) (STX1A))

Andere Bezeichnung: STX1A

Hintergrund: Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis. Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1253 BC064644.1 1-1253 1254-2117 BC000444.2 1209-2072
Alias Symbols: HPC-1, STX1, p35-1, P35-1, SYN1A
Protein Interaction Partner: STXBP1, SUMO1P1, TXLNA, TXLNB, NAPB, VAMP5, SNAP29, VAPB, SNAP23, STX1A, PSMA3, KCNB1, Htt, SNAP25, SLC6A3, SLC6A2, PPP1CA, pnut, Sep1, SNPH, TRDMT1, CCSER2, VPS11, SYT7, VPS18, RIMS1, CPLX1, SLC6A5, STXBP5, SYTL4, STXBP6, UNC13B, STX8, RAB27A, NAPA, VAMP
Protein Size: 288

Molekulargewicht: 33 kDa

Gen-ID: 6804

NCBI Accession: NM_004603, NP_004594

UniProt: Q16623

Pathways: Peptide Hormone Metabolism, Synaptic Membrane, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport