Serotonin Receptor 1A Antikörper (N-Term)

Produktnummer ABIN2792271

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Serotonin Receptor 1A in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für Serotonin Receptor 1A Antikörper (N-Term) (ABIN2792271)

Target: Serotonin Receptor 1A (HTR1A)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Serotonin Receptor 1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Serotonin Receptor 1A Antikörper

Bindungsspezifität: N-Term

Sequenz: GQGNNTTSPP APFETGGNTT GISDVTVSYQ VITSLLLGTL IFCAVLGNAC

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HTR1A. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HTR1A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 422 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Serotonin Receptor 1A Antikörper (ABIN2792271)

Adeosun, Albert, Austin, Iyo: "17?-estradiol-induced regulation of the novel 5-HT1A-related transcription factors NUDR and Freud-1 in SH SY5Y cells." in: Cellular and molecular neurobiology, Vol. 32, Issue 4, pp. 517-21, (2012) (PubMed).

Szewczyk, Albert, Rogaeva, Fitzgibbon, May, Rajkowska, Miguel-Hidalgo, Stockmeier, Woolverton, Kyle, Wang, Austin: "Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 13, Issue 8, pp. 1089-101, (2010) (PubMed).

Szewczyk, Albert, Burns, Czesak, Overholser, Jurjus, Meltzer, Konick, Dieter, Herbst, May, Rajkowska, Stockmeier, Austin: "Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 2, pp. 155-68, (2009) (PubMed).

Cordeaux, Pasupathy, Bacon, Charnock-Jones, Smith: "Characterization of serotonin receptors in pregnant human myometrium." in: The Journal of pharmacology and experimental therapeutics, Vol. 328, Issue 3, pp. 682-91, (2009) (PubMed).

Iyo, Kieran, Chandran, Albert, Wicks, Bissette, Austin: "Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress." in: Neuroscience, Vol. 163, Issue 4, pp. 1119-27, (2009) (PubMed).

Details zu Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Andere Bezeichnung: HTR1A

Hintergrund: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibits adenylate cyclase activity.
Alias Symbols: 5HT1a, 5-HT1A, ADRBRL1, ADRB2RL1
Protein Interaction Partner: UBC, RHOA, GABBR2, GPR26, S1PR1, S1PR3, HTR1D, HTR1B, GNAI3, HTR1A,
Protein Size: 422

Molekulargewicht: 46 kDa

Gen-ID: 3350

NCBI Accession: NM_000524, NP_000515

UniProt: P08908

Pathways: JAK-STAT Signalweg, Synaptic Membrane, Feeding Behaviour