SPTA1 Antikörper (N-Term)

Produktnummer ABIN2792075

Dieses Anti-SPTA1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SPTA1 in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd und Kaninchen.

Kurzübersicht für SPTA1 Antikörper (N-Term) (ABIN2792075)

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPTA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SPTA1 Antikörper

Bindungsspezifität: N-Term

Sequenz: DELSGWMNEK TAAINADELP TDVAGGEVLL DRHQQHKHEI DSYDDRFQSA

Homologie: Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SPTA1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SPTA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SPTA1

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Andere Bezeichnung: SPTA1

Hintergrund: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
Alias Symbols: EL2, HPP, HS3, SPH3, SPTA
Protein Interaction Partner: ANK1, PTPRO, UBC, YWHAQ, MYBL2, PTPN22, BTK, UBASH3B, SHC1, CBL, FASLG, NCOA3, ENAH, EVL, SPTBN2, ABI1, VASP, PLEC, SLC9A2, FANCC, SPTB, ADD1, ACTA1, ABL1, EZR, FANCA, ERCC4,
Protein Size: 2419

Molekulargewicht: 266 kDa

Gen-ID: 6708

NCBI Accession: NM_003126, NP_003117

UniProt: P02549

Pathways: Regulation of Actin Filament Polymerization