KDELR2 Antikörper (C-Term)

Produktnummer ABIN2790796

Der Kaninchen Polyklonal Anti-KDELR2-Antikörper wurde für WB validiert. Er ist geeignet, KDELR2 in Proben von Human zu detektieren.

Kurzübersicht für KDELR2 Antikörper (C-Term) (ABIN2790796)

Target: KDELR2 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 2 (KDELR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDELR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KDELR2 Antikörper

Bindungsspezifität: C-Term

Sequenz: ASVLQGARTE FLPQQRHKML DTENQKLNSF VADSHQWLCK NAEEKSQKVS

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KDELR2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human KDELR2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 186 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KDELR2

Target: KDELR2 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 2 (KDELR2))

Andere Bezeichnung: KDELR2

Hintergrund: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83 % identical to the KDELR1 gene product.
Alias Symbols: ELP-1, ERD2.2, FLJ45532
Protein Interaction Partner: UBC, ELAVL1, SERINC3,
Protein Size: 186

Molekulargewicht: 21 kDa

Gen-ID: 11014

NCBI Accession: NM_001100603, NP_001094073

Pathways: Maintenance of Protein Location