MYSM1 Antikörper (C-Term)

Produktnummer ABIN2790657

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MYSM1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Hund und Kaninchen.

Kurzübersicht für MYSM1 Antikörper (C-Term) (ABIN2790657)

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Reaktivität: Human, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYSM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MYSM1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: MYSM1 Antibody - C-terminal region

Sequenz: CLQKLLECMR KTLSKVTNCF MAEEFLTEIE NLFLSNYKSN QENGVTEENC

Homologie: Dog: 86%, Human: 100%, Rabbit: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against MYSM1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MYSM1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP67188-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu MYSM1

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Andere Bezeichnung: MYSM1

Hintergrund:

Background Information: MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.

Alternative Symbols: 2ADUB, BMFS4, 2A-DUB

Protein Name: Histone H2A deubiquitinase MYSM1

Molekulargewicht: 91kDa

Gen-ID: 114803

NCBI Accession: NP_001078956

UniProt: Q5VVJ2

Pathways: Chromatin Binding