POF1B Antikörper (N-Term)

Produktnummer ABIN2790494

Produktdetails anti-POF1B Antikörper

Target: POF1B (Premature Ovarian Failure, 1B (POF1B))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POF1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: HYHCYHQSSQ AQQPPEKNVV YERVRTYSGP MNKVVQALDP FNSREVLSPL

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against POF1B. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human POF1B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 589 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu POF1B

Target: POF1B (Premature Ovarian Failure, 1B (POF1B))

Andere Bezeichnung: POF1B (POF1B Produkte)

Hintergrund: Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined.
Alias Symbols: FLJ22792, POF, POF2B
Protein Interaction Partner: ESR1, COPS5, UBC, Cdk1, Akap12, Fam134a, Lyplal1, Tpr, UCHL5,
Protein Size: 589

Molekulargewicht: 65 kDa

Gen-ID: 79983

NCBI Accession: NM_024921, NP_079197

UniProt: Q8WVV4