LGMN Antikörper (Middle Region)

Produktnummer ABIN2790480

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch LGMN in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd und Zebrafisch (Danio rerio).

Kurzübersicht für LGMN Antikörper (Middle Region) (ABIN2790480)

Target: LGMN (Legumain (LGMN))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LGMN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LGMN Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: LGMN Antibody - middle region

Sequenz: KMVFYIEACE SGSMMNHLPD NINVYATTAA NPRESSYACY YDEKRSTYLG

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 79%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 93%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against LGMN. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human LGMN

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP66605-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu LGMN

Target: LGMN (Legumain (LGMN))

Andere Bezeichnung: LGMN

Hintergrund:

Background Information: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.

Alternative Symbols: AEP, LGMN1, PRSC1

Protein Name: Legumain

Molekulargewicht: 48kDa

Gen-ID: 5641

NCBI Accession: NP_005597

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades