PIK3C2A Antikörper (C-Term)

Produktnummer ABIN2790304

Der Kaninchen Polyklonal anti-PIK3C2A Antikörper wird verwendet zum Nachweis von PIK3C2A in Proben von Human, Maus, Ratte, Hund, Schwein, Pferd, Kaninchen und Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für PIK3C2A Antikörper (C-Term) (ABIN2790304)

Target: PIK3C2A (Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIK3C2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PIK3C2A Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PIK3C2A Antibody - C-terminal region

Sequenz: PNPYVKTYLL PDNHKTSKRK TKISRKTRNP TFNEMLVYSG YSKETLRQRE

Homologie: Dog: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against PIK3C2A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human PIK3C2A

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP65938-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PIK3C2A

Target: PIK3C2A (Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))

Andere Bezeichnung: PIK3C2A

Hintergrund:

Background Information: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

Gene Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Alternative Symbols: CPK, OCSKD, PI3-K-C2A, PI3K-C2alpha, PI3K-C2-alpha, PI3-K-C2(ALPHA)

Protein Name: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Molekulargewicht: 143kDa

Gen-ID: 5286

NCBI Accession: NP_002636

UniProt: O00443

Pathways: EGFR Signaling Pathway, Inositol Metabolic Process, Platelet-derived growth Factor Receptor Signaling