PDE8B Antikörper (Middle Region)

Produktnummer ABIN2789902

Der Kaninchen Polyklonal anti-PDE8B Antikörper (ABIN2789902) detektiert spezifisch PDE8B in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Pferd, Rind (Kuh), Hund, Schwein, Meerschweinchen, Ratte und Zebrafisch (Danio rerio).

Kurzübersicht für PDE8B Antikörper (Middle Region) (ABIN2789902)

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Reaktivität: Human, Maus, Pferd, Rind (Kuh), Hund, Schwein, Meerschweinchen, Ratte, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE8B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PDE8B Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: PDE8B Antibody - middle region

Sequenz: TELYSPQLGT KDEDPHTSDL VGGLMTDGLR RLSGNEYVFT KNVHQSHSHL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against PDE8B. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64625-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Andere Bezeichnung: PDE8B

Hintergrund:

Background Information: The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.

Gene Name: Phosphodiesterase 8B

Alternative Symbols: ADSD, PPNAD3

Protein Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Molekulargewicht: 87kDa

Gen-ID: 8622

NCBI Accession: NP_001025022

UniProt: O95263

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process