UNC13D Antikörper (C-Term)

Produktnummer ABIN2789769

Der Kaninchen Polyklonal anti-UNC13D Antikörper wird verwendet zum Nachweis von UNC13D in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen und Pferd. Er wurde validiert für WB.

Kurzübersicht für UNC13D Antikörper (C-Term) (ABIN2789769)

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNC13D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-UNC13D Antikörper

Bindungsspezifität: C-Term

Sequenz: SGSEEPGEVP QTRLPLTYPA PNGDPILQLL EGRKGDREAQ VFVRLRRHRA

Homologie: Cow: 92%, Dog: 93%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 86%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against UNC13D. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human UNC13D

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu UNC13D

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Andere Bezeichnung: UNC13D

Hintergrund: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Alias Symbols: FHL3, HLH3, HPLH3, Munc13-4
Protein Interaction Partner: UBC, CUL5, VPS37B, XRN2, LMNA, RAB27B, RAB27A,
Protein Size: 1090

Molekulargewicht: 119 kDa

Gen-ID: 201294

NCBI Accession: NM_199242, NP_954712

UniProt: Q70J99

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process