WISP2 Antikörper (C-Term)

Produktnummer ABIN2789751

Der Kaninchen Polyklonal Anti-WISP2-Antikörper wurde für WB validiert. Er ist geeignet, WISP2 in Proben von Human, Ratte, Hund, Pferd und Schwein zu detektieren.

Kurzübersicht für WISP2 Antikörper (C-Term) (ABIN2789751)

Target: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Reaktivität: Human, Ratte, Hund, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WISP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-WISP2 Antikörper

Bindungsspezifität: C-Term

Sequenz: WGPCSTTCGL GMATRVSNQN RFCRLETQRR LCLSRPCPPS RGRSPQNSAF

Homologie: Dog: 79%, Horse: 79%, Human: 100%, Pig: 79%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against WISP2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 250 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu WISP2

Target: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Andere Bezeichnung: WISP2

Hintergrund: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72 % identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Alias Symbols: CCN5, CT58, CTGF-L
Protein Interaction Partner: HDAC3, HDAC1, IGF1R, IGF2R,
Protein Size: 250

Molekulargewicht: 24 kDa

Gen-ID: 8839

NCBI Accession: NM_003881, NP_003872

UniProt: O76076

Pathways: WNT Signalweg, Growth Factor Binding