CD276 Antikörper (C-Term)

Produktnummer ABIN2789671

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CD276 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Pferd, Rind (Kuh), Kaninchen, Hund, Schwein und Meerschweinchen.

Kurzübersicht für CD276 Antikörper (C-Term) (ABIN2789671)

Target: CD276

Reaktivität: Human, Maus, Ratte, Pferd, Rind (Kuh), Kaninchen, Hund, Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD276 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CD276 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: CD276 Antibody - C-terminal region

Sequenz: VCLIALLVAL AFVCWRKIKQ SCEEENAGAE DQDGEGEGSK TALQPLKHSD

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 86%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CD276. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63929-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CD276

Target: CD276

Andere Bezeichnung: CD276

Hintergrund:

Background Information: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: CD276 Molecule

Alternative Symbols: B7H3, B7-H3, B7RP-2, 4Ig-B7-H3

Protein Name: CD276 antigen

Molekulargewicht: 34kDa

Gen-ID: 80381

NCBI Accession: NP_079516

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints