PLAU Antikörper (C-Term)

Produktnummer ABIN2789605

Dieses Anti-PLAU-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PLAU in WB. Geeignet für Human, Kaninchen, Pferd und Saccharomyces cerevisiae.

Kurzübersicht für PLAU Antikörper (C-Term) (ABIN2789605)

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Reaktivität: Human, Kaninchen, Pferd, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLAU Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PLAU Antikörper

Bindungsspezifität: C-Term

Sequenz: CSLQGRMTLT GIVSWGRGCA LKDKPGVYTR VSHFLPWIRS HTKEENGLAL

Homologie: Horse: 86%, Human: 100%, Rabbit: 86%, Yeast: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PLAU. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 431 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PLAU

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Andere Bezeichnung: PLAU

Hintergrund: This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Alias Symbols: ATF, UPA, URK, u-PA, QPD, BDPLT5
Protein Interaction Partner: TEX101, UBC, PLAUR, SUMO1, NEDD8, CEBPG, ELAVL1, MYC, BTK, ALAS1, SCAMP5, PDGFC, ST14, SERPINA5, LRP2, SERPINF2, F2, SERPINB2, PLAT, SERPINE1, PLG, SERPINB6, IGF2R, HGF, NID1, CTSL, CTSB, MAP2K1, HRAS, SERPINE2,
Protein Size: 431

Molekulargewicht: 28 kDa

Gen-ID: 5328

NCBI Accession: NM_002658, NP_002649

UniProt: P00749

Pathways: Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagie, Smooth Muscle Cell Migration