PDE6B Antikörper (C-Term)

Produktnummer ABIN2789553

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PDE6B in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Meerschweinchen und Kaninchen.

Kurzübersicht für PDE6B Antikörper (C-Term) (ABIN2789553)

Target: PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE6B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PDE6B Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PDE6B Antibody - C-terminal region

Sequenz: RQHEHVIHLM DIAIIATDLA LYFKKRAMFQ KIVDESKNYQ DKKSWVEYLS

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 79%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against PDE6B. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63580-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PDE6B

Target: PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))

Andere Bezeichnung: PDE6B

Hintergrund:

Targeted Subunit: beta

Background Information: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: Phosphodiesterase 6B, cGMP-specific, rod, beta

Alternative Symbols: rd1, PDEB, RP40, CSNB3, CSNBAD2, GMP-PDEbeta

Protein Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Molekulargewicht: 98kDa

Gen-ID: 5158

NCBI Accession: NP_001138764

UniProt: E7ETT3

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction