Macrophage Scavenger Receptor 1 Antikörper (N-Term)

Produktnummer ABIN2789552

Der Kaninchen Polyklonal anti-Macrophage Scavenger Receptor 1 Antikörper (ABIN2789552) detektiert spezifisch Macrophage Scavenger Receptor 1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Schwein, Hund, Pferd und Rind (Kuh).

Kurzübersicht für Macrophage Scavenger Receptor 1 Antikörper (N-Term) (ABIN2789552)

Target: Macrophage Scavenger Receptor 1 (MSR1)

Reaktivität: Human, Schwein, Hund, Pferd, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Macrophage Scavenger Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Macrophage Scavenger Receptor 1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: MSR1 Antibody - N-terminal region

Sequenz: VSSTNANDIT QSLTGKGNDS EEEMRFQEVF MEHMSNMEKR IQHILDMEAN

Homologie: Cow: 82%, Dog: 93%, Horse: 85%, Human: 100%, Pig: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against MSR1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63579-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Andere Bezeichnung: MSR1

Hintergrund:

Background Information: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Gene Name: Macrophage scavenger receptor 1

Alternative Symbols: SRA, SR-A, CD204, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII

Protein Name: Macrophage scavenger receptor types I and II

Molekulargewicht: 50kDa

Gen-ID: 4481

NCBI Accession: NP_619729

UniProt: P21757