Macrophage Scavenger Receptor 1 Antikörper (N-Term)

Produktnummer ABIN2789552

Dieses Anti-Macrophage Scavenger Receptor 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Macrophage Scavenger Receptor 1 in WB. Geeignet für Human, Schwein, Hund, Rind (Kuh) und Pferd.

Kurzübersicht für Macrophage Scavenger Receptor 1 Antikörper (N-Term) (ABIN2789552)

Target: Macrophage Scavenger Receptor 1 (MSR1)

Reaktivität: Human, Schwein, Hund, Rind (Kuh), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Macrophage Scavenger Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Macrophage Scavenger Receptor 1 Antikörper

Bindungsspezifität: N-Term

Sequenz: VSSTNANDIT QSLTGKGNDS EEEMRFQEVF MEHMSNMEKR IQHILDMEAN

Homologie: Cow: 82%, Dog: 93%, Horse: 85%, Human: 100%, Pig: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against MSR1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 451 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Andere Bezeichnung: MSR1

Hintergrund: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Alias Symbols: CD204, SCARA1, SR-A, phSR1, phSR2, SRA
Protein Interaction Partner: SEC22A, LEPROTL1, MALL, NKG7, ATP6V0C, IQCB1, TRAF6, HSPA1A,
Protein Size: 451

Molekulargewicht: 50 kDa

Gen-ID: 4481

NCBI Accession: NM_138715, NP_619729

UniProt: P21757