SOCS2 Antikörper (C-Term)

Produktnummer ABIN2789498

Der Kaninchen Polyklonal anti-SOCS2 Antikörper wird verwendet zum Nachweis von SOCS2 in Proben von Human, Ratte, Maus, Rind (Kuh), Schwein, Hund, Kaninchen und Meerschweinchen. Er wurde validiert für WB.

Kurzübersicht für SOCS2 Antikörper (C-Term) (ABIN2789498)

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Schwein, Hund, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SOCS2 Antikörper

Bindungsspezifität: C-Term

Sequenz: KQFDSVVHLI DYYVQMCKDK RTGPEAPRNG TVHLYLTKPL YTSAPSLQHL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SOCS2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 198 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Andere Bezeichnung: SOCS2

Hintergrund: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
Alias Symbols: CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Protein Interaction Partner: Tceb1, CUL5, UBC, FLT3, ARFIP2, TPD52, PLA2G1B, BMI1, SOCS3, LCK, GHR, CCNC, RYBP, PTK2B, RNF7, TCEB2, EPOR, PTK2, PRLR, INSR, IGF1R, SOCS1,
Protein Size: 198

Molekulargewicht: 22 kDa

Gen-ID: 8835

NCBI Accession: NM_003877, NP_003868

UniProt: O14508

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus