HAS1 Antikörper (N-Term)

Produktnummer ABIN2789475

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HAS1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund und Meerschweinchen.

Kurzübersicht für HAS1 Antikörper (N-Term) (ABIN2789475)

Target: HAS1 (Hyaluronan Synthase 1 (HAS1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HAS1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: HAS1 Antibody - N-terminal region

Sequenz: EPAAAGAVGA GAYREVEAED PGRLAVEALV RTRRCVCVAQ RWGGKREVMY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HAS1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63382-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu HAS1

Target: HAS1 (Hyaluronan Synthase 1 (HAS1))

Andere Bezeichnung: HAS1

Hintergrund:

Background Information: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis.

Gene Name: Hyaluronan synthase 1

Alternative Symbols: HAS

Protein Name: Hyaluronan synthase 1

Molekulargewicht: 64kDa

Gen-ID: 3036

NCBI Accession: NP_001514

UniProt: Q92839

Pathways: Glycosaminoglycan Metabolic Process