HAS1 Antikörper (N-Term)

Produktnummer ABIN2789475

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HAS1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Hund und Meerschweinchen.

Kurzübersicht für HAS1 Antikörper (N-Term) (ABIN2789475)

Target: HAS1 (Hyaluronan Synthase 1 (HAS1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HAS1 Antikörper

Bindungsspezifität: N-Term

Sequenz: EPAAAGAVGA GAYREVEAED PGRLAVEALV RTRRCVCVAQ RWGGKREVMY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HAS1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 578 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HAS1

Target: HAS1 (Hyaluronan Synthase 1 (HAS1))

Andere Bezeichnung: HAS1

Hintergrund: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis.
Alias Symbols: HAS
Protein Interaction Partner: EWSR1, DDX1, VHL, EIF6,
Protein Size: 578

Molekulargewicht: 64 kDa

Gen-ID: 3036

NCBI Accession: NM_001523, NP_001514

UniProt: Q92839

Pathways: Glycosaminoglycan Metabolic Process