Desmoglein 1 Antikörper (C-Term)

Produktnummer ABIN2789462

Der Kaninchen Polyklonal anti-Desmoglein 1 Antikörper wird verwendet zum Nachweis von Desmoglein 1 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für Desmoglein 1 Antikörper (C-Term) (ABIN2789462)

Target: Desmoglein 1 (DSG1)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Desmoglein 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Desmoglein 1 Antikörper

Bindungsspezifität: C-Term

Sequenz: GGIGLSSLGG TASIGHMRSS SDHHFNQTIG SASPSTARSR ITKYSTVQYS

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against DSG1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human DSG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Desmoglein 1

Target: Desmoglein 1 (DSG1)

Andere Bezeichnung: DSG1

Hintergrund: This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.
Alias Symbols: DG1, DSG, CDHF4, EPKHE, PPKS1, SPPK1, EPKHIA
Protein Size: 408

Molekulargewicht: 44 kDa

Gen-ID: 1828

NCBI Accession: NM_001942, NP_001933

UniProt: B7Z845

Pathways: Cell-Cell Junction Organization