VKORC1 Antikörper (N-Term)

Produktnummer ABIN2789450

Dieser Anti-VKORC1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von VKORC1 in WB und IHC. Geeignet für Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen und Pferd.

Kurzübersicht für VKORC1 Antikörper (N-Term) (ABIN2789450)

Target: VKORC1 (Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VKORC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-VKORC1 Antikörper

Bindungsspezifität: N-Term

Sequenz: LHVKAARARD RDYRALCDVG TAISCSRVFS SRLPADTLGL CPDAAELPGV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against VKORC1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of VKORC1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 92 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu VKORC1

Target: VKORC1 (Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1))

Andere Bezeichnung: VKORC1

Hintergrund: Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.
Alias Symbols: EDTP308, FLJ00289, IMAGE3455200, MGC2694, MST134, MST576, VKCFD2, VKOR
Protein Interaction Partner: UBC, ILK, ZMYM6NB, TMEM242, SNORA12, TMEM256, ZCCHC24, METTL7B, SPTSSA, VKORC1L1, CCDC167, CCDC12, TMEM45B, KCNK17, JAGN1, SERP1, PPA2, TRAM1, TREX1, YIF1A, EBP, ARL6IP5, PROCR, IFITM3, ATP6AP2, BCAP31, PDIA6, HDAC6, HOMER2, VAPB, CLDN10, DPM2, REEP5, TF,
Protein Size: 92

Molekulargewicht: 10 kDa

Gen-ID: 79001

NCBI Accession: NM_206824, NP_996560

UniProt: Q9BQB6