NLRP3 Antikörper (N-Term)

Produktnummer ABIN2789437

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NLRP3 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Kaninchen, Rind (Kuh), Hund, Schwein und Pferd.

Kurzübersicht für NLRP3 Antikörper (N-Term) (ABIN2789437)

Target: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Reaktivität: Human, Kaninchen, Rind (Kuh), Hund, Schwein, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NLRP3 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: NLRP3 Antibody - N-terminal region

Sequenz: LGESVSLNKR YTRLRLIKEH RSQQEREQEL LAIGKTKTCE SPVSPIKMEL

Homologie: Cow: 93%, Dog: 79%, Horse: 93%, Human: 100%, Pig: 93%, Rabbit: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against NLRP3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63297-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu NLRP3

Target: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Andere Bezeichnung: NLRP3

Hintergrund:

Background Information: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).

Gene Name: NLR family, pyrin domain containing 3

Alternative Symbols: AII, AVP, FCU, MWS, FCAS, KEFH, CIAS1, FCAS1, NALP3, C1orf7, CLR1.1, DFNA34, PYPAF1, AGTAVPRL

Protein Name: NACHT, LRR and PYD domains-containing protein 3

Molekulargewicht: 114kDa

Gen-ID: 114548

NCBI Accession: NP_004886

UniProt: Q96P20

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome