HCK Antikörper (C-Term)

Produktnummer ABIN2788734

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HCK in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen.

Kurzübersicht für HCK Antikörper (C-Term) (ABIN2788734)

Target: HCK (Hemopoietic Cell Kinase (HCK))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HCK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HCK Antikörper

Bindungsspezifität: C-Term

Sequenz: LVKLHAVVTK EPIYIITEFM AKGSLLDFLK SDEGSKQPLP KLIDFSAQIA

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 79%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against HCK. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human HCK

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 504 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HCK

Target: HCK (Hemopoietic Cell Kinase (HCK))

Andere Bezeichnung: HCK

Hintergrund: The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.
Alias Symbols: JTK9, p59Hck, p61Hck
Protein Interaction Partner: NOTCH2NL, KRTAP10-9, KRT40, GOPC, MTUS2, SPRR2A, STAT3, ACTB, Mbp, MED28, RUFY1, WNT2, HSP90AA1, ERBB3, ABL2, CBL, APP, PAK2, nef, TNK2, ADAM15, CREBBP, FASLG, SH3KBP1, KHDRBS1, MYC, UBC, SRC, MAP4K5, CHST15, ELMO1, SF3B3, EVL, IRF2BPL, SH3BP1, INPP5D, AG
Protein Size: 504

Molekulargewicht: 55 kDa

Gen-ID: 3055

NCBI Accession: NM_001172131, NP_001165602

UniProt: P08631

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling