Endothelin 3 Antikörper (C-Term)

Produktnummer ABIN2788707

Dieses Anti-Endothelin 3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Endothelin 3 in WB. Geeignet für Human und Schwein.

Kurzübersicht für Endothelin 3 Antikörper (C-Term) (ABIN2788707)

Target: Endothelin 3 (EDN3)

Reaktivität: Human, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Endothelin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Endothelin 3 Antikörper

Bindungsspezifität: C-Term

Sequenz: LHFCTQTLDV SSNSRTAEKT DKEEEGKVRG ANRGLCQRRL KSRTNKASRL

Homologie: Human: 100%, Pig: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against EDN3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EDN3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 219 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Endothelin 3

Target: Endothelin 3 (EDN3)

Andere Bezeichnung: EDN3

Hintergrund: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
Alias Symbols: ET3, MGC15067, MGC61498, ET-3, WS4B, HSCR4, PPET3
Protein Interaction Partner: EDNRB, EDNRA, CMA1, CTSE, KEL,
Protein Size: 219

Molekulargewicht: 24 kDa

Gen-ID: 1908

NCBI Accession: NM_207032, NP_996915

UniProt: P14138

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones