Histone H3.3 Antikörper (N-Term)

Produktnummer ABIN970851

Dieses Anti-Histone H3.3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Histone H3.3 in WB. Geeignet für Ratte, Schwein, Zebrafisch (Danio rerio) und Hund.

Kurzübersicht für Histone H3.3 Antikörper (N-Term) (ABIN970851)

Target: Histone H3.3 (H3F3A) (H3 Histone, Family 3A (H3F3A))

Reaktivität: Ratte, Schwein, Zebrafisch (Danio rerio), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Histone H3.3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Histone H3.3 Antikörper

Bindungsspezifität: N-Term

Sequenz: KSAPSTGGVK KPHRYRPGTV ALREIRRYQK STELLIRKLP FQRLVREIAQ

Homologie: Dog: 100%, Pig: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against H3f3a. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 126 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Histone H3.3

Target: Histone H3.3 (H3F3A) (H3 Histone, Family 3A (H3F3A))

Andere Bezeichnung: H3f3a

Hintergrund: H3f3a is a variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. H3f3a constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. H3f3a is deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Alias Symbols: H3.3A, H3f3b, MGC102150
Protein Interaction Partner: Kmt2d, Chd5, Setd1a, Kmt2c, Setd1b, Ezh2, Chd1, Cbx3, Uhrf1, Nfkb2, Hdac5, Hdac3, Kdm6b, Nfe2, Aurka, Cbx2, Ehmt2, Cbx5, Aurkb, Cbx6, Bptf, Creb3l4, Ing2, Cbx7, Cbx8, Cbx4, Cd4, Fosb, Rps6ka5, Rps6ka3, Igh-8, Cd79a, Tcrb, Eif2s3x, Kdm5c, Nanog, Kcnq1ot1,
Protein Size: 126

Molekulargewicht: 15 kDa

Gen-ID: 15078

NCBI Accession: NM_008210, NP_032236

UniProt: P84244