PYM Antikörper (C-Term)

Produktnummer ABIN2788485

Dieses Anti-PYM-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PYM in WB. Geeignet für Human, Maus, Rind (Kuh), Hund, Pferd, Meerschweinchen, Kaninchen, Ratte, Saccharomyces cerevisiae und Schwein.

Kurzübersicht für PYM Antikörper (C-Term) (ABIN2788485)

Target: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Reaktivität: Human, Maus, Rind (Kuh), Hund, Pferd, Meerschweinchen, Kaninchen, Ratte, Saccharomyces cerevisiae, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PYM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PYM Antikörper

Bindungsspezifität: C-Term

Sequenz: KKIKNLKKKL RQVEELQQRI QAGEVSQPSK EQLEKLARRR ALEEELEDLE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against WIBG. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human WIBG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 204 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PYM

Target: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Andere Bezeichnung: WIBG

Hintergrund: WIBG is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. It acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. It interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions.
Alias Symbols: MGC13064, PYM
Protein Interaction Partner: RTN4IP1, UBC, RPS19, RPS14, RPS13, RPS12, RPS10, RPS9, RPS8, RPS7, RPS6, RPS5, RPS4X, RPS3A, RPS3, RPS2, FAU, BYSL, ZNF503, PNO1, KCMF1, TSR1, RPS27L, UBQLN1, RPS29, RPS28, RPS27, RPS26, RPS25, RPS24, RPS23, RPS20, RPS18, RPS16, RPS15A, TARDBP, MAGOH, TOE
Protein Size: 204

Molekulargewicht: 23 kDa

Gen-ID: 84305

NCBI Accession: NM_032345, NP_115721

UniProt: Q9BRP8