TCHP Antikörper (C-Term)

Produktnummer ABIN2788476

Produktdetails anti-TCHP Antikörper

Target: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TCHP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: IQEKIEQNRR AQEESLKHRE QLIRNLEEVR ELARREKEES EKLKSARKQE

Homologie: Cow: 100%, Dog: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Yeast: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against TCHP. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TCHP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 498 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TCHP Antikörper (ABIN2788476)

Wong, Vaz, Lee, Zhao, Luo, Archer, Preiss, Tanavde, Vardy: "Embryonic Stem Cells Exhibit mRNA Isoform Specific Translational Regulation." in: PLoS ONE, Vol. 11, Issue 1, pp. e0143235, (2016) (PubMed).

Details zu TCHP

Target: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Andere Bezeichnung: TCHP (TCHP Produkte)

Synonyme: TpMs antikoerper, A930031F18Rik antikoerper, AV279199 antikoerper, RGD1310813 antikoerper, zgc:136634 antikoerper, trichoplein keratin filament binding antikoerper, trichoplein, keratin filament binding antikoerper, trichoplein, keratin filament binding L homeolog antikoerper, TCHP antikoerper, tchp antikoerper, Tchp antikoerper, tchp.L antikoerper

Hintergrund: TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
Alias Symbols: MGC10854, TpMs
Protein Interaction Partner: CCDC172, MIPOL1, DYDC1, KRT40, LZTS2, NME7, NDOR1, MKRN3, TRIM27, NAB2, KRT15, CDR2, UBC, LATS2, CUL4A, CCDC85B, TEX11, VIM, KRT18, KRT16, KRT14, KRT8, KRT6A, KRT5,
Protein Size: 498

Molekulargewicht: 61 kDa

Gen-ID: 84260

NCBI Accession: NM_032300, NP_115676

UniProt: Q9BT92