FGFR2 Antikörper (C-Term)

Produktnummer ABIN2788319

Der Kaninchen Polyklonal anti-FGFR2 Antikörper (ABIN2788319) detektiert spezifisch FGFR2 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Meerschweinchen, Kaninchen, Pferd, Hund, Rind (Kuh), Zebrafisch (Danio rerio) und Schaf.

Kurzübersicht für FGFR2 Antikörper (C-Term) (ABIN2788319)

Target: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Kaninchen, Pferd, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FGFR2 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: FGFR2 Antibody - C-terminal region

Sequenz: KPKEAVTVAV KMLKDDATEK DLSDLVSEME MMKMIGKHKN IINLLGACTQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against FGFR2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FGFR2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60044-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu FGFR2

Target: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Andere Bezeichnung: FGFR2

Hintergrund:

Background Information: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene Name: Fibroblast growth factor receptor 2

Alternative Symbols: BEK, JWS, BBDS, CEK3, CFD1, ECT1, KGFR, TK14, TK25, BFR-1, CD332, K-SAM

Protein Name: Fibroblast growth factor receptor 2

Molekulargewicht: 78kDa

Gen-ID: 2263

NCBI Accession: NP_075259

UniProt: P21802

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding