AP2A2 Antikörper (C-Term)

Produktnummer ABIN2788288

Produktdetails anti-AP2A2 Antikörper

Target: AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AP2A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LAKLKKKKGP STVTDLEDTK RDRSVDVNGG PEPAPASTSA VSTPSPSADL

Homologie: Dog: 79%, Guinea Pig: 79%, Human: 100%, Mouse: 79%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against AP2A2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human AP2A2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 939 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu AP2A2

Target: AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Andere Bezeichnung: AP2A2 (AP2A2 Produkte)

Hintergrund: AP2A2 is a component of the adaptor protein complex 2 (AP-2). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif .
Alias Symbols: ADTAB, CLAPA2, HIP9, HYPJ, HIP-9
Protein Interaction Partner: PIP5K1C, UBC, ATP1A1, SUMO2, EGFR, RPA3, RPA2, RPA1, BIN1, PPP6R3, PAN2, SMAD1, FN1, DAB2, VCP, APP, AP2A1, SHC1, GRK5, EPS15, AP2M1, CLTC, GRB2, ARRB2, Rnf111, TERF2, DNAJC6, SNAP91, EPN1, AP2A2, NUMB, AP1S1, DNM1, AP2B1, AMPH, HTT, ATR, ATM, RALBP1,
Protein Size: 939

Molekulargewicht: 104 kDa

Gen-ID: 161

NCBI Accession: NM_012305, NP_036437

UniProt: O94973

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation, SARS-CoV-2 Protein Interaktom