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AP2A2 Antikörper

AP2A2 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7111308
  • Target Alle AP2A2 Antikörper anzeigen
    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
    Reaktivität
    • 41
    • 28
    • 11
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 40
    • 1
    Kaninchen
    Klonalität
    • 41
    Polyklonal
    Konjugat
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AP2A2 Antikörper ist unkonjugiert
    Applikation
    • 33
    • 13
    • 13
    • 12
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Aufreinigung
    Immunogen affinity purified
    Reinheit
    ≥95 % as determined by SDS-PAGE
    Immunogen
    adaptor-related protein complex 2, alpha 2 subunit
    Isotyp
    IgG
    Top Product
    Discover our top product AP2A2 Primärantikörper
  • Applikationshinweise
    WB: 1:200-1:1000, IHC: 1:20-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Haltbarkeit
    12 months
  • Target
    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
    Andere Bezeichnung
    AP2A2 (AP2A2 Produkte)
    Synonyme
    MGC99219 antikoerper, ADTAB antikoerper, CLAPA2 antikoerper, HIP-9 antikoerper, HIP9 antikoerper, HYPJ antikoerper, 2410074K14Rik antikoerper, AF006990 antikoerper, AW146353 antikoerper, Adtab antikoerper, C78001 antikoerper, L25 antikoerper, adaptor related protein complex 2 alpha 2 subunit antikoerper, adaptor related protein complex 2 alpha 2 subunit L homeolog antikoerper, adaptor-related protein complex 2, alpha 2 subunit antikoerper, AP2A2 antikoerper, ap2a2.L antikoerper, Ap2a2 antikoerper
    Hintergrund
    Synonyms:ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899 Background:Component of the adaptor protein complex 2(AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin(clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein(AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV](Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif(By similarity).
    Molekulargewicht
    104 kDa
    Gen-ID
    161
    UniProt
    O94973
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation, SARS-CoV-2 Protein Interaktom
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