BTBD12 Antikörper (N-Term)

Produktnummer ABIN2788239

Dieses Anti-BTBD12-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BTBD12 in WB. Geeignet für Human und Kaninchen.

Kurzübersicht für BTBD12 Antikörper (N-Term) (ABIN2788239)

Target: BTBD12 (BTB (POZ) Domain Containing 12 (BTBD12))

Reaktivität: Human, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BTBD12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BTBD12 Antikörper

Bindungsspezifität: N-Term

Sequenz: TKTLQGPAEK KPPSGSQAPR TKKQRVTKWQ ASEPAHSVNG EGGVLASAPD

Homologie: Human: 100%, Rabbit: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against BTBD12. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human BTBD12

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1834 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BTBD12

Target: BTBD12 (BTB (POZ) Domain Containing 12 (BTBD12))

Andere Bezeichnung: BTBD12

Hintergrund: This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
Alias Symbols: KIAA1784, KIAA1987, MUS312, SLX4, FANCP, BTBD12
Protein Interaction Partner: MUS81, vpr, SLX1A, SLX1B, DCLRE1B, TERF2, ERCC4, UBC, ERCC1, APP, EME1, PCNA, MSH2, MSH6, DDB1, SLX4IP, SPRTN, TERF2IP, VCP, PLK1, SUMO2, PGAM5, DCAF10, LRRC1, GID8, TEX10, GLTSCR2, NUP188, NUP50, PNMA2, TSPYL1, PSMB4, MSH3, KPNA1,
Protein Size: 1834

Molekulargewicht: 200 kDa

Gen-ID: 84464

NCBI Accession: NM_032444, NP_115820

UniProt: Q8IY92

Pathways: DNA Reparatur