RASSF5 Antikörper (C-Term)

Produktnummer ABIN2788157

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RASSF5 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen.

Kurzübersicht für RASSF5 Antikörper (C-Term) (ABIN2788157)

Target: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASSF5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RASSF5 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Rassf5 Antibody - C-terminal region

Sequenz: SFVLKENETG EVEWDAFSIP ELQNFLTILE KEEQDKIHQL QKKYNKFRQK

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against Rassf5. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Rassf5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59675-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu RASSF5

Target: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Andere Bezeichnung: Rassf5

Hintergrund:

Background Information: Rassf5 is a potental tumor suppressor. It seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. It may be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.

Gene Name: Ras association (RalGDS/AF-6) domain family member 5

Alternative Symbols: No, Nor, Rapl, Maxp1, Nore1, Nore1A, Nore1B, 1300019G20Rik

Protein Name: Ras association domain-containing protein 5

Molekulargewicht: 47kDa

Gen-ID: 54354

NCBI Accession: NP_061220

UniProt: Q5EBH1

Pathways: T-Zell Rezeptor Signalweg