Metabotropic Glutamate Receptor 3 Antikörper (N-Term)

Produktnummer ABIN2788132

Der Kaninchen Polyklonal anti-Metabotropic Glutamate Receptor 3 Antikörper (ABIN2788132) detektiert spezifisch Metabotropic Glutamate Receptor 3 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Rind (Kuh), Pferd, Kaninchen, Hund, Meerschweinchen und Zebrafisch (Danio rerio).

Kurzübersicht für Metabotropic Glutamate Receptor 3 Antikörper (N-Term) (ABIN2788132)

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Pferd, Kaninchen, Hund, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Metabotropic Glutamate Receptor 3 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: GRM3 Antibody - N-terminal region

Sequenz: NHRNPWFRDF WEQKFQCSLQ NKRNHRRVCD KHLAIDSSNY EQESKIMFVV

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against GRM3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human GRM3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59602-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Metabotropic Glutamate Receptor 3

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Andere Bezeichnung: GRM3

Hintergrund:

Background Information: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Gene Name: glutamate receptor, metabotropic 3

Alternative Symbols: GLUR3, mGlu3, GPRC1C, MGLUR3

Protein Name: metabotropic glutamate receptor 3

Molekulargewicht: 82kDa

Gen-ID: 2913

NCBI Accession: NP_000831

UniProt: Q14832

Pathways: cAMP Metabolic Process, Synaptic Membrane