COCH Antikörper (N-Term)

Produktnummer ABIN2788127

Der Kaninchen Polyklonal anti-COCH Antikörper wird verwendet zum Nachweis von COCH in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen und Pferd. Er wurde validiert für WB.

Kurzübersicht für COCH Antikörper (N-Term) (ABIN2788127)

Target: COCH (Cochlin (COCH))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COCH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-COCH Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: COCH Antibody - N-terminal region

Sequenz: AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR FNLQKNFVGK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against COCH. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human COCH

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59585-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu COCH

Target: COCH (Cochlin (COCH))

Andere Bezeichnung: COCH

Hintergrund:

Background Information: The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.

Gene Name: Coagulation factor C homolog, cochlin (Limulus polyphemus)

Alternative Symbols: DFNA9, COCH5B2, DFNB110, COCH-5B2

Protein Name: Cochlin

Molekulargewicht: 57kDa

Gen-ID: 1690

NCBI Accession: NP_001128530

UniProt: O43405

Pathways: Sensory Perception of Sound