USP8 Antikörper (N-Term)

Produktnummer ABIN2788009

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch USP8 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Schwein, Ratte, Rind (Kuh), Hund und Pferd.

Kurzübersicht für USP8 Antikörper (N-Term) (ABIN2788009)

Target: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Reaktivität: Human, Schwein, Ratte, Rind (Kuh), Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-USP8 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: USP8 Antibody - N-terminal region

Sequenz: KGSLENVLDS KDKTQKSNGE KNEKCETKEK GAITAKELYT MMTDKNISLI

Homologie: Cow: 85%, Dog: 85%, Horse: 92%, Human: 100%, Pig: 85%, Rat: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against USP8. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human USP8

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59292-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu USP8

Target: USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Andere Bezeichnung: USP8

Hintergrund:

Background Information: USP8 is a hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. USP8 catalytic activity is enhanced in the M phase. USP8 is involved in cell proliferation. USP8 is required to enter into S phase in response to serum stimulation. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. USP8 probably regulates the stability of STAM2 and RASGRF1. USP8 regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle.USP8 deubiquitinates EPS15 and controles tyrosine kinase stability.USP8 removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. USP8 is involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.

Gene Name: Ubiquitin specific peptidase 8

Alternative Symbols: UBPY, PITA4, SPG59, HumORF8

Protein Name: Ubiquitin carboxyl-terminal hydrolase 8

Molekulargewicht: 127kDa

Gen-ID: 9101

NCBI Accession: NP_005145

UniProt: P40818